"Objective: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications. Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear. Research Design and Methods: We investigated the relations of serum 25-hydroxyvitamin D (25[OH]D) concentrations with indices of cardiometabolic risk in 3,890 non-diabetic individuals; 1,882 had subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes measured by multi-detector computed tomography (CT). Results: In multivariable-adjusted regression models, 25(OH)D was inversely associated with winter season, waist circumference, and serum insulin ( P<0.005 for all). In models further adjusted for CT measures, 25(OH)D was inversely related to SAT (-1.1 ng/mL per standard deviation [SD] increment in SAT, P=0.016) and VAT (-2.3 ng/mL per SD, P<0.0001). The association of 25(OH)D with insulin resistance measures became non-significant after adjustment for VAT. Higher adiposity volumes were correlated with lower 25(OH)D across different categories of body mass index (BMI), including in lean individuals (BMI <25 kg/m(2)). The prevalence of vitamin D deficiency (25(OH)D <20 ng/mL ) was 3-fold higher in those with high SAT and high VAT than in those with low SAT and low VAT (P<0.0001). Conclusion: Vitamin D status is strongly associated with variation in subcutaneous and especially visceral adiposity. The mechanisms by which adiposity promotes vitamin D deficiency warrant further study."
Allting är möjligt tills det är bevisat som omöjligt - och till och med då är det omöjliga kanske bara omöjligt än så länge." /Pearl Buck♥· Medarbetare påHealing